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Propranolol may reduce the oxygen requirement of the heart and so decreases its demand for oxygen. Care should be taken if adrenaline is given with Propranolol, laboratory determinations should be made at regular intervals. Beta-blockers. Care should be taken if adrenaline is given with Propranolol, laboratory determinations should be made at regular intervals. There may be increased difficulty in treating an allergic type reaction in patients on beta-blockers.
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