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Have been known to make certain conditions worse, including asthma, diabetes, epilepsy, migraine. Long-term conjugated estrogens treatment may increase your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. This medication may interfere with some laboratory tests. Premarin is also controversial because the health risks to women of absorbing a substance made from equine waste may not be fully known. Do not use conjugated estrogens if you are taking antidepressants or a thyroid medication.
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